141-30-0, 3,6-Dichloropyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a stirred suspension of 2,2-dimethylpropanoic acid (0.288 g, 2.82 mmol) and 3,6-dichloropyridazine (0.299 g, 2 mmol) in water (3 ml_) at 55C was added AgN03 (0.068 g, 0.4 mmol) as a solution in water (0.3 ml_) followed by TFA (0.046 g, 0.4 mmol). (NH4)2S208 (0.778 g, 3.19 mmol) was added dropwise as a solution in water (1.5 ml_). The reaction mixture was then heated to 75C for 1 h. Upon cooling the reaction mixture was poured into NaHC03 solution (15 ml_) and extracted with CH2CI2 (15 ml) twice. The combined organic fractions were dried over MgS04, filtered and the solvent removed by evaporation in vacuo. Purification by silica gel column chromatography, 3:1 CH2CI2/hexane elution, yielded intermediate 1 (0.33 g, 80%). LCMS (ESI): Found 205.0 [M+Hf.
141-30-0, 141-30-0 3,6-Dichloropyridazine 67331, apyridazine compound, is more and more widely used in various fields.
Reference£º
Patent; KARUS THERAPEUTICS LIMITED; SHUTTLEWORTH, Stephen Joseph; GATLAND, Alice Elizabeth; FINNEMORE, Daniel John; ALEXANDER, Rikki Peter; SILVA, Franck; CECIL, Alexander; (233 pag.)WO2019/166824; (2019); A1;,
Pyridazine – Wikipedia
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