Related Products of 35857-89-7, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 35857-89-7, Name is 6-Chloropyridazine-3-carbonitrile, molecular formula is C5H2ClN3. In a Article，once mentioned of 35857-89-7
We have previously reported on antitussive effect of (5R,9R,13S,14S)-17-cyclopropylmethyl-6,7-didehydro-4,5-epoxy-5?,6?-dihydro-3-methoxy-4?H-pyrrolo[3,2,1-ij]quinolino[2?,1?:6,7]morphinan-14-ol(1b) methanesulfonate (TRK-850), a selective delta opioid receptor antagonist which markedly reduced the number of coughs in a rat cough model. We designed TRK-850 based on naltrindole (NTI), a typical delta opioid receptor antagonist, to improve its permeability through the blood-brain barrier by introducing hydrophobic moieties to NTI. The ED50 values of NTI and compound 1b by intraperitoneal injections were 104 mug/kg and 2.07 mug/kg, respectively. This increased antitussive potency probably resulted from the improved brain exposure of compound 1b. However, 1b was extremely unstable toward metabolism by cytochrome P450. In this study, we designed and synthesized compound 1b derivatives to improve the metabolic instability, which resulted in affording highly potent and metabolically stable oral antitussive agent (5R,9R,13S,14S)-17-cyclopropylmethyl-6,7-didehydro-4,5-epoxy-8?-fluoro-5?,6?-dihydro-4?H-pyrrolo[3,2,1-ij]quinolino[2?,1?:6,7]morphinan-3,14-diol (1c) methanesulfonate (TRK-851).
The potential utility of systematic synthetic strategy will be applicable to efficient generations of chemical libraries of compounds to find ‘hit’ molecules.Read on for other articles about 35857-89-7Related Products of 35857-89-7
Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N968 – PubChem