With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.51149-08-7,3,6-Dichloropyridazine-4-carboxylic acid,as a common compound, the synthetic route is as follows.
51149-08-7, Example 5( 6-Chloro-1 H -indol-3-yl)[ 6-chloro-[3-( 4-.fluorobenzyl)amino ]pyridazin-4-yl]methanone 3,6-Dichloropyridazine-4-carbonyl chloride. 3,6-Dichloropyridazine-4-carboxylic acid (Aldrich; 1.13 g, 5.86 mmol) in toluene (20 mL) containing 2 drops of DMF was treated with neat SOCI2 (4 mL). The mixture heated to reflux for 3h and then allowed to cool. The resulting red-orange mixture was decanted and cone, in vacuo. The residue was redis solved in toluene and cone to give 1.22 g of the product.
51149-08-7 3,6-Dichloropyridazine-4-carboxylic acid 433804, apyridazine compound, is more and more widely used in various fields.
Reference£º
Patent; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; HOGENKAMP, Derk; WO2013/169907; (2013); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem