20744-39-2, Pyridazin-4-amine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Example 292-{[(4-Fluorophenyl)methyl]oxy}-4-(1 -methyl-1 H-pyrazol-4-yl)-5-(4- morpholinylcarbonyl)-/V-4-pyridazinylbenzamide (E29) To a solution of (4-fluorophenyl)methyl 2-{[(4-fluorophenyl)methyl]oxy}-4-(1-methyl-1 H- pyrazol-4-yl)-5-(4-morpholinylcarbonyl)benzoate (may be prepared as described inDescription 32; 191 mg, 0.35 mmol) in tetrahydrofuran (6 ml) was added lithium hydroxide (60 mg, 2.51 mmol) and water (1.5 ml). The mixture was stirred for 3 hours then quenched with 2M hydrochloric acid (1.26 ml, 2.51 mmol). The solvent was removed in vacuo and the residue was redissolved in N,N-dimethylformamide (6 ml) and diisopropylethylamine (0.12 ml, 0.70 mmol), 4-pyridazinamine (39.8 mg, 0.42 mmol), 1-hydroxy-7-azabenzotriazole (57.0 mg, 0.42 mmol) and EDC (100 mg, 0.52 mmol) were added. The reaction was stirred for 18 hours then the solvent was removed in vacuo and the residue purified by MDAP to yield the title compound as a white solid. 64 mg.MS (electrospray): m/z, [M+H]+ = 5171 H NMR (400 MHz, DMSO-d6); 2.74 – 3.13 (3 H, m), 3.35 – 3.75 (5 H, m), 3.86 – 3.96 (3 H, m), 5.33 (2 H, s), 7.15 – 7.29 (2 H, m), 7.43 (1 H, s), 7.50 – 7.66 (3 H, m), 7.74 (1 H, s), 7.94 – 8.07 (2 H, m), 8.95 – 9.10 (1 H, m), 9.20 (1 H, d, J=1.76 Hz), 10.69 (1 H, s)., 20744-39-2
The synthetic route of 20744-39-2 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; GLAXO GROUP LIMITED; ANDREOTTI, Daniele; DAI, Xuedong; EATHERTON, Andrew John; JANDU, Karamjit Singh; LIU, Qian; PHILPS, Oliver James; WO2012/28629; (2012); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem