Product Details of 141-30-0, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Article, and a compound is mentioned, 141-30-0, 3,6-Dichloropyridazine, introducing its new discovery.
Syntheses and IC50 values for the displacement of 3H-diazepam from rat brain plasma membrane are reported for a series of 6-benzylamino(and methoxybenzylamino)-3-methoxy-2-phenyl(substituted phenyl and pyridinyl)imidazo<1,2-b>pyridazines (and their 6-anilino and 6-phenethylamino analogues).The results are compared with those reported previously (by us) for the 6-chloro, 6-phenoxy, 6-benzylthio, and 6-benzyloxy compounds.In the imidazo<1,2-b>pyridazine ring system, 6-(o- and m-methoxybenzylamino) groups were found to be beneficial to binding activity; eight compounds have been prepared with IC50 values less than 2 nM (cf. 3H-diazepam with IC50 of 4.2 nM). 2-(p-Aminophenyl)-3-methoxy-6-(m-methoxybenzylamino)imidazo<1,2-b>pyridazine exhibited the highest activity with IC50 1.0 nM.
Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research. 141-30-0 is helpful to your research. Product Details of 141-30-0
Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N1608 – PubChem