Modeling chemical reactions helps engineers virtually understand the chemistry, optimal size and design of the system, and how it interacts with other physics that may come into play. Recommanded Product: 6-Chloropyridazine-3-carbonitrile
With the purpose of expanding the structural variety of chemical compounds available as pharmacological tools for the treatment of Alzheimer’s disease, we synthesized and evaluated a novel series of indole-benzoxazinones (Family I) and benzoxazine-arylpiperazine derivatives (Family II) for potential human acetylcholinesterase (hAChE) inhibitory properties. The most active compounds 7a and 7d demonstrated effective inhibitory profiles with Ki values of 20.3 ± 0.9 muM and 20.2 ± 0.9 muM, respectively. Kinetic inhibition assays showed non-competitive inhibition of AChE by the tested compounds. According to our docking studies, the most active compounds from both series (Families I and II) showed a binding mode similar to donepezil and interact with the same residues.
Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research. 35857-89-7 is helpful to your research. Recommanded Product: 6-Chloropyridazine-3-carbonitrile
Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N948 – PubChem