With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5469-70-5,3-Aminopyridazine,as a common compound, the synthetic route is as follows.
To a stirred solution of pyridazin-3-amine (2.9g, 30.5mmol) and pyridine (7.4 mL, 91.5mmol) in THF (40mL) and DMA (20mL) was added 2,2,2-Trichloroethyl chloroformate (6.31mL, 45.7mmol) at 0C dropwise. The mixture was stirred at 0C for 1.0h, poured into water, and extracted with EtOAc. The organic layer was washed with water, dried over anhydrous MgSO4, and concentrated in vacuo. The residue was recrystallized from EtOAc-hexane to give 23 (3.76g, 46%) as an off-white crystals 1H NMR (300MHz, CDCl3) delta: 4.88 (2H, s), 7.50-7.55 (1H, m), 8.25-8.28 (1H, m), 8.74 (1H, br s), 8.95-8.97 (1H, m)., 5469-70-5
5469-70-5 3-Aminopyridazine 230373, apyridazine compound, is more and more widely used in various fields.
Reference£º
Article; Kono, Mitsunori; Matsumoto, Takahiro; Imaeda, Toshihiro; Kawamura, Toru; Fujimoto, Shinji; Kosugi, Yohei; Odani, Tomoyuki; Shimizu, Yuji; Matsui, Hideki; Shimojo, Masato; Kori, Masakuni; Bioorganic and Medicinal Chemistry; vol. 22; 4; (2014); p. 1468 – 1478;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem