120276-59-7, 3-Chloro-6-(chloromethyl)pyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
A mixture of N-(3-(trifluoromethyl)phenyl)tetrahydro-2H-thiopyran-4-carboxamide 1,1- dioxide (150 mg, 0.467 mmol), 3-chloro-6-(chloromethyl)pyridazine (152 mg, 0.934 mmol) and potassium carbonate (129 mg, 0.934 mmol) in DMF (3 mL) was placed in a microwave tube and heated at 80 C for 0.5 h. The contents in the flask were diluted with ethyl acetate (30 mL) and water (20 mL). The phases were separated, and the organics washed with brine (2 x 30 mL), dried over Na2SO4, filtered and concentrated in vacuo. The residue was purified by flash silica gel chromatography (ISCO; 4 g SepaFlash Silica Flash Column, Eluent of 0-40% MeOH/DCM gradient 18 mL/min) followed by prep-TLC (SiO2, DCM: MeOH=10:1) to give N-((6-chloropyridazin-3-yl)methyl)-N-(3-(trifluoromethyl) phenyl) tetrahydro-2H-thiopyran-4-carboxamide 1,1-dioxide as an oil. ESI-MS m/z [M+CN] +: 448.0.
As the paragraph descriping shows that 120276-59-7 is playing an increasingly important role.
Reference£º
Patent; MERCK SHARP & DOHME CORP.; WALJI, Abbas; BERGER, Richard; STUMP, Craig, A.; SCHLEGEL, Kelly Ann, S.; MULHEARN, James, J.; GRESHOCK, Thomas, J.; WANG, Deping; FRALEY, Mark, E.; JONES, Kristen, G.; (273 pag.)WO2017/222951; (2017); A1;,
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