With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.14161-11-6,3,4,5-Trichloropyridazine,as a common compound, the synthetic route is as follows.
Example 157 4-Isopropylamino-3,5-dichloropyridazine 3,4,5-Trichloropyridazine (9.2 g 0.05 mol) is dissolved in toluene (24 ml). Isopropylamine (16.5 g, 0.28 mol) is added and the mixture refluxed three hrs. The solution is cooled, diluted with chloroform and sodium hydroxide (1N). The organic phase is separated, washed with water and saline, then dried over sodium sulfate, filtered and concentrated. The concentrate is chromatographed (silica gel, 300 g; ethyl acetate/hexane (30/70)) to give the title compound, NMR (300 MHz, CDCl3) 8.50, 4.74, 4.47 and 1.20delta., 14161-11-6
The synthetic route of 14161-11-6 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Pharmacia & Upjohn Company; US5866589; (1999); A;,
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