One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, Recommanded Product: 3-Phenyl-6-chloropyridazine, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 20375-65-9, Name is 3-Phenyl-6-chloropyridazine, molecular formula is C10H7ClN2
Macrocyclic receptor 1 has been synthesised, as a racemate and as a single enantiomer, utilising a Stille coupling for the formation of the biphenyl portion and a macrolactamisation as the final step. The binding properties for the racemic and the homochiral macrocycle with amino acid and dipeptide derivatives, in CDCl3 solution, have been investigated. In the case of racemic 1, addition of homochiral peptide substrates led to two distinct diastereomeric complexes, and the well separated signals for several protons in the 1H NMR spectrum could be conveniently followed in titration experiments, allowing determination of both binding constants for the two diastereoisomeric complexes, and indicating that 1 is capable of enantioselective recognition. Titration of homochiral 1 with the same peptide substrates allowed the sense of the enantioselectivity to be determined, and experiments with a greater range of substrates indicated that 1 is particularly effective for the recognition of N-Cbz-beta-alanyl-L-amino acids, the strongest binding being observed with N-Cbz-beta-alanyl-L-alanine (- DeltaG(ass)= 19.9 kJ mol-1). Notably the binding of N-Cbz-beta-alanyl-L-lactic acid was considerably weaker (-DeltaG(ass)= 13.1 kJ mol-1), presumably due to replacement of an NH hydrogen-bond donor in the case of N-Cbz-beta-alanyl-L- alanine with an oxygen lone-pair in the case of N-Cbz-beta-alanyl-L-lactic acid. Molecular modelling and 2D NMR studies on the free macrocycle 1 and associated complexes did not provide conclusive evidence for the structure of the host-guest complexes, but did serve to emphasise the flexibility of 1, which despite this flexibility, shows strong, selective binding of certain peptide guests.
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Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N2617 – PubChem