Properties and Exciting Facts About 3,6-Dichloro-4,5-dimethylpyridazine

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SAR of a novel series of pyridazine-derived gamma-secretase modulators is described. Compound 25 was found to be a potent modulator in vitro, which on further profiling, was found to decrease Abeta42 and Abeta40, and maintain the levels of total Abeta. Furthermore, 25 demonstrated excellent pharmacokinetic parameters as well as good CNS penetration in the rat.

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Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2477 – PubChem