With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.135034-10-5,3-Chloro-6-iodopyridazine,as a common compound, the synthetic route is as follows.
To a stirred solution of Intermediate 2 (0.25 g, 0.8 mmol) in dry DMF (5 mL), TEA (0.36 ml,2.85 mmol) and 3-chloro-6-iodopyridazine (0.123 g, 0.99 mmol) were added at rt and the reaction mixture was stirred at 90 C overnight. The resulting reaction mixture was cooled to rt and DMF was evaporated under reduced pressure. To the resulting crude mixture, water (20 mL) was added and the product was extracted with EtOAc (2 x 30 mL). Theresulting organic layer was dried over Na2SO4 and concentrated. This crude product waspurified by flash column chromatography to afford the title compound ( off white solid). 1HNMR (400 MHz, CDCI3): 68.86-8.84 (m, 2H), 8.11 (d, J = 8.8 Hz, IH), 8.03 (d, J = 2.0 Hz,I H), 7.90 (dd, J = 8.8, 2.0 Hz, I H), 7.45 (d, J = 9.6 Hz, I H), 6.60 (d, J = 9.6 Hz, I H), 3.65-3.58 (m, 5H), 2.73-2.67 (m, 2H), 2.59-2.54 (m, 2H), 1.51 (d, J = 6.8 Hz, 3H). LCMS:(Method A) 447.0 (M +H), Rt. 2.13 mm, 99.59% (Max). HPLC: (Method A) Rt. 2.16 mm,98.99% (Max).
135034-10-5, As the paragraph descriping shows that 135034-10-5 is playing an increasingly important role.
Reference£º
Patent; ASCENEURON S. A.; QUATTROPANI, Anna; KULKARNI, Santosh, S.; GIRI, Awadut, Gajendra; (280 pag.)WO2017/144633; (2017); A1;,
Pyridazine – Wikipedia
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