With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.932-22-9,4,5-Dichloro-3(2H)-pyridazinone,as a common compound, the synthetic route is as follows.,932-22-9
General procedure: To a solutionof 4,5-dichloropyridazin-3(2H)-one (1, 3.0 mmol) andEt3N (3.6 mmol) in CH2Cl2 (30 mL) was added dropwise theappropriate alkyl/aryl chloroformate (2, 3.9 mmol) and themixture was stirred for 10 min at 5 C (Scheme 1). Thereaction mixture was washed using water (5 ¡Á 50 mL). Theorganic layer was dried over anhydrous magnesium sulfate,and then evaporated under reduced pressure. The resultingresidue was recrystallized from THF/n-hexane (1:3, v/v) togive the product 3.
932-22-9 4,5-Dichloro-3(2H)-pyridazinone 73247, apyridazine compound, is more and more widely used in various fields.
Reference£º
Article; Sung, Gi Hyeon; Bo, Ram Kim; Ryu, Ki Eun; Kim, Jeum-Jong; Yoon, Yong-Jin; Bulletin of the Korean Chemical Society; vol. 35; 9; (2014); p. 2758 – 2764;,
Pyridazine – Wikipedia
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