Related Products of 34127-22-5, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.34127-22-5, Name is Ethyl 3,6-dichloropyridazine-4-carboxylate, molecular formula is C7H6Cl2N2O2. In a Article，once mentioned of 34127-22-5
A series of pyridines and other six-membered ring heterocycles connected to a biphenyltetrazole with a-CH2-NR’-link (1) were discovered to be potent angiotensin II antagonists.In the pyrimidine carboxylic acid series (W = CR, X = N, Y = CH, Z = COOH), compounds with an alkyl group (R’) on the exocyclic nitrogen were much more potent than compounds with an alkyl group (R) on the heterocyclic ring.The corresponding pyridine, pyridazine, pyrazine, and 1,2,4-triazine carboxylic acids also showed potent in vitro angiotensin II antagonism.The pyridine (W, X, Y = CH, Z = COOH, R’ = n-C3H7) demonstrated potent in vitro activity (pA2 = 10.10, rabbit aorta, and Ki = 0.61 nM, receptor binding in rat liver) as well as exceptional oral antihypertensive activity and bioavailability.Any nonacidic replacement for the carboxylic acid was detrimental for activity.
We’ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 34127-22-5, and how the biochemistry of the body works.Related Products of 34127-22-5
Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N2959 – PubChem