Some scientific research about 3,6-Dichloro-4,5-dimethylpyridazine

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In heterogeneous catalysis, the catalyst is in a different phase from the reactants. Product Details of 34584-69-5, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 34584-69-5, name is 3,6-Dichloro-4,5-dimethylpyridazine. In an article,Which mentioned a new discovery about 34584-69-5

We describe an extensive SAR study in the 6-[4-fluoro-3-(substituted)benzyl]-4,5-dimethylpyridazin-3(2H)-one series which led to the identification of potent PARP-1 inhibitors, capable of inhibiting the proliferation of BRCA-1 deficient cancer cells in the low nanomolar range, and displaying >100-fold selectivity over the BRCA wild type counterparts. The series of compounds was devoid of hERG channel activity, and CYP inhibition and induction liabilities. Several analogs were stable in rat and human liver microsomes and displayed moderate rat clearance, with urinary excretion of parent as the major route of elimination.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 34584-69-5, help many people in the next few years.Product Details of 34584-69-5

Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2471 – PubChem