1722-10-7, 3-Chloro-6-methoxypyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Reference Example 227 To a mixture of4- [3- (methoxymethoxy) propyl]-3- (1-methylethyl)-lH-pyrazole (1.00 g), 3-chloro-6- methoxypyridazine (0.82 g) and N, N-dimethylformamide (15 ml) was added sodium hydride(60%, in oil, 0.24 g) at0 C, and, after termination of hydrogen generation, the mixture was stirred at room temperature for 3 hours. The reaction mixture was poured into water, and the precipitated crystals were collected by filtration and washed with water. A mixture of the obtained wet crystals,conc. hydrochloric acid (3 drops) and methanol (15 ml) was refluxed for 4 hours. The reaction mixture was poured into ice water, and the precipitated crystals were collected by filtration, washed with water, dried and subjected to silica gel column chromatography, and 3-{1-[6-methOxypyridazin-3-yl]-3-(1-methylethyl)-lH-pyrazol-4-yl}-1-propanol (300 mg, yield23%) was obtained as a colorless oil from a fraction eluted with acetone-chloroform (1: 4, volume ratio). melting point:122-123 C. 1H-NMR(CDC13) $ : 1.32 (6H, d, J= 6.9Hz), 1.39(1H, t, J= 5.3Hz), 1.84-1. 97 (2H, m), 2.60 (2H, t, J= 7.7Hz), 3.03 (1H, septet, J= 7.0Hz), 3.75 (2H, q, J= 5.8Hz), 4.12 (3H, s), 7.06(1H, d, J= 9.3Hz), 8.11(1H, d, J= 9.3Hz), 8.32(1H, s).
1722-10-7, The synthetic route of 1722-10-7 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; TAKEDA CHEMICAL INDUSTRIES, LTD.; WO2003/99793; (2003); A1;,
Pyridazine – Wikipedia
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