With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.88491-61-6,3-Bromopyridazine,as a common compound, the synthetic route is as follows.,88491-61-6
To a reaction flask were added compound 5 (200 mg, 0.392 mmol), 3-bromopyridazine (92.9 mg, 0.588 mmol), Pd(dppf)Cl2 (32 mg, 0.02 mmol) and sodium carbonate (126 mg, 1.18 mmol), 2 mL glycol dimethyl ether and 0.4 mL water were added, bubbled with nitrogen gas for 10 minutes, and the reaction was heated to 120 C in microwave and reacted for half an hour. After TLC detected the reaction was complete, the reaction was concentrated, purified by silica gel column chromatography to afford 57 mg of a product, yield: 31.7%. LC-MS(APCI): m/z = 462.1(M+1)+; 1H NMR (400 MHz, DMSO) delta 10.26 (s, 1H), 9.24 (d, J = 3.4 Hz, 1H), 8.84 (d, J = 2.2 Hz, 1H), 8.20 (d, J = 2.2 Hz, 1H), 7.87 (t, J = 7.7 Hz, 3H), 7.80 (dd, J = 8.4, 4.9 Hz, 1H), 7.33 (d, J = 8.8 Hz, 2H), 4.87 (d, J = 3.3 Hz, 1H), 4.20 (s, 1H), 3.44 – 3.36 (m, 1H), 3.17 (d, J = 5.3 Hz, 2H), 2.82 (d, J = 11.2 Hz, 1H), 1.85 (dd, J = 8.6, 4.3 Hz, 1H), 1.74 (s, 1H).
The synthetic route of 88491-61-6 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Shenzhen Targetrx, Inc.; WANG, Yihan; ZHAO, Jiuyang; AL, Yixin; (55 pag.)EP3553056; (2019); A1;,
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