34231-77-1, Methyl pyridazine-4-carboxylate is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a solution of 18-crown-6 (0.48 g, 1.8 mM) in tetrahydrofuran (10 mL), there was added a 1.0M potassium tert-butoxide/tetrahydrofuran solution (20 mL, 20 mM) and then the mixture was warmed up to 60 C. Acetonitrile (1.0 mL, 20 mM) was added to the mixture at that temperature, the mixture was stirred for 10 minutes and 4-methoxycarbonyl-pyridazine (2.5 g, 18 mM) was then added thereto. After stirring the mixture at 60 C. for 30 minutes, it was cooled to room temperature, the precipitated solid was recovered through filtration and then washed with tetrahydrofuran. After drying the resulting solid in vacuo, it was suspended in ethanol (50 mL) and then methyl carbazinate (2.3 g, 26 mM) was added thereto. Concentrated hydrochloric acid (1.5 mL) was added to the suspension with ice-cooling and the mixture was stirred at that temperature for 14 hours. The reaction liquid was concentrated under reduced pressure and the excess hydrochloric acid was neutralized by the addition of a saturated sodium bicarbonate aqueous solution. The reaction liquid was extracted with ethyl acetate, the organic phase thus obtained was dried over anhydrous magnesium sulfate and concentrated under reduced pressure to thus give a crude product of the title compound (0.50 g, yield: 13%). MS (ESI) m/z (M+H)+ 220, 34231-77-1
34231-77-1 Methyl pyridazine-4-carboxylate 12439252, apyridazine compound, is more and more widely used in various fields.
Reference£º
Patent; AJINOMOTO CO., INC.; US2011/294781; (2011); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem