1837-55-4, 3,5-Dichloropyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Step 1 Ethyl (cis)-2-r(6-chloropyridazin-4-yl) amino] cyclohexanecarboxylate (I- 22a)3,5-dichloropyridazine (1.6 g, 10.74 mmol), ethyl (cis)-2-aminocyclohexanecarboxylate hydrochloride(CA, 2.454 g, 11.81 mmol), and triethylamine (5.63 mL, 32.2mmol) were added to DMSO (10.0 ml) and heated for 5 hrs at 120 C and then allowed to stir at room temperature for 24hr. Solvents were removed in vacuo. The residue was dissolved in EtOAc and then poured into sat. sodium bicarb. The aqeuous layer was removed and back extracted with EtOAc. The combined organics were washed with brine, dried over sodium sulfate and concentrated to an oil. Purification on biotage again (DCM:MeOH, 0-9%B) and concentration afforded the product, I-22a, as a solid (2.207g, 71.7%). LRMS (ESI) m/z 284.0 [(M+H)+; calcd for C13H18C1N302: 284.0].
As the paragraph descriping shows that 1837-55-4 is playing an increasingly important role.
Reference£º
Patent; MERCK SHARP & DOHME CORP.; BUTCHER, John, W.; WITTER, David; DINSMORE, Christopher; KIM, June; HENDRIX, John; ARCHARYA, Raksha; AHEARN, Sean, P.; JUNG, Joon; RIVKIN, Alexey; JONES, Philip; WO2013/52355; (2013); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem