Brief introduction of 4,5-Dichloro-3(2H)-pyridazinone

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Electric Literature of 932-22-9. In my other articles, you can also check out more blogs about 932-22-9

Electric Literature of 932-22-9, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 932-22-9, Name is 4,5-Dichloro-3(2H)-pyridazinone, molecular formula is C4H2Cl2N2O. In a Article,once mentioned of 932-22-9

Amyloid plaques, which are primarily composed of aggregated amyloid-beta (Abeta) peptide, are the neuropathological hallmarks of Alzheimer’s disease (AD). Fluorescent markers containing 2-styrylpyridazin-3(2H)-ones were developed to detect intracellular aggregated Abeta peptides. Nine compounds exhibited a greater than 10-fold increase of in emission spectra before and after mixing with Abeta aggregates compared with before mixing. Among these compounds, compound 9n exhibited the highest affinity for Abeta aggregates (Kd = 1.84 muM) and selectively stained both aggregated intracellular Abeta and Abeta plaques in the transgenic AD model mice (APP/PS1). These preliminary results indicate that 2-styrylpyridazin-3(2H)-one derivatives are promising alternative fluorescence imaging agent for the study of AD.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Electric Literature of 932-22-9. In my other articles, you can also check out more blogs about 932-22-9

Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2347 – PubChem