With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.932-22-9,4,5-Dichloro-3(2H)-pyridazinone,as a common compound, the synthetic route is as follows.
4,5-dichloropyridazin-3-one (20.06 g, 122.3 mmol)And POCl3 (117 mL, 1280 mmol)The mixture was stirred at reflux for 3 hours.After the reaction,The mixture was cooled to room temperature.A mixed suspension of water and ice (100 mL) was then added.The resulting mixture was adjusted to pH = 10 with saturated aqueous Na 2CO 3.It was then extracted with EtOAc (250 mL x 3).The combined organic layers were washed with brine brine (250 mL)Filter and concentrate under reduced pressure.The residue was purified by silica gel column chromatography (EtOAc /EtOAcThe title compound was obtained as a white solid (17.80 g, yield: 79.3%)., 932-22-9
The synthetic route of 932-22-9 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Jiatuo Sciences Corporation; Xi Ning; Li Minxiong; Peng Ju; Li Xiaobo; Zhang Tao; Hu Haiyang; Chen Wuhong; Bai Changlin; Ke Donghua; Chen Peng; (217 pag.)CN109776522; (2019); A;,
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