The synthetic route of 2166-31-6 has been constantly updated, and we look forward to future research findings.
With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2166-31-6,6-Phenylpyridazin-3(2H)-one,as a common compound, the synthetic route is as follows.
Example 123; l-(3-Morpholinopropyl)-3-(3-((6-oxo-3-phenyIpyridazin-l(6H)- yl)methyl)phenyl)urea (1) A mixture of 6-phenylpyridazin-3(2H)-one (4.1 g, 24 mmol), K2CO3 (3.3 g, 24 mmol), and l-(bromomethyl)-3 -nitrobenzene (5.1 g, 24 mmol) in DMF (25 mL) was stirred at rt for 1 day. The mixture was diluted with H2O (50 mL) and stirred for 30 min. The suspension was filtered, washed with H2O and dried in air to give a white solid (6.8 g). LCMS (ESI pos. ion): calc’d for Ci7Hi3N3O3:307.1; found 308.1 (M+l). 1H NMR (300 MHz, CHLOROFORM-d) delta ppm 5.49 (s, 2 H) 7.05 (d, J-9.65 Hz, 1 H) 7.42 – 7.57 (m, 4 H) 7.71 (d, J=9.79 Hz, 1 H) 7.75 – 7.80 (m, 2 H) 7.83 (d, J=7.60 Hz, 1 H) 8.17 (dd, J=8.18, 2.05 Hz, 1 H) 8.35 (t, J=I .75 Hz, 1 H)., 2166-31-6
The synthetic route of 2166-31-6 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; AMGEN INC.; WO2008/103277; (2008); A2;,
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