With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.51149-08-7,3,6-Dichloropyridazine-4-carboxylic acid,as a common compound, the synthetic route is as follows.
3-hydrazino-4-carboxy-6-chloro-pyridazine A mixture of 3,6-dichloro-4-carboxy-pyridazine (20 g; 0.103 mole) and 22 ml of 98% hydrazine hydrate in 200 ml of 50% ethanol was refluxed, under stirring, for one hour. After cooling at 5 C., the solid precipitate was collected, washed with 20 ml of anhydrous ethanol. The solid was suspended in 100 ml of water, the mixture was brought to pH 1-2 with 23% HCl, after cooling at 5 C. the solid was filtered, dried under vacuum at 80 C. to give 18.29 g (93.4%) of the title compound, m.p. 198-201 C. Elemental analysis: found: C, 31.64; H, 2.64; N, 29.32; Cl, 18.53; calculated for C5 H5 ClN4 O2: C, 31.84; H, 2.67; N, 29.71; Cl, 18.80., 51149-08-7
The synthetic route of 51149-08-7 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Farmitalia Carlo Erba S.p.A.; US4331666; (1982); A;,
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