93319-65-4,93319-65-4, Pyridazin-3-ylmethanamine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a solution of phenyl (3,5-difluoro-4-{[3-(trifluoromethyl)-1 -{[2-(trimethylsilyl)ethoxy]methyl}- 1 H-pyrrolo[2,3-b]pyridin-4-yl]oxy}phenyl)carbamate (150 mg, 259 muetaetaomicronIota, intermediate 1 ) in DMF (1 .3 mL) was added 1 -(pyridazin-3-yl)methanamine (28.2 mg, 259 muetaetaomicronIota) and this mixture was stirred at 55 C over night. Additional 1 -(pyridazin-3-yl)methanamine (14.1 mg, 129 muetaetaomicronIota) was added and stirred over night at 60C. After cooling to room temperature ethyl acetate and water was added. After separation of the organic phase the aqueous phase was extracted two times with ethyl acetate. The combined organic phases were washed with brine, dried over sodium sulfate, filtered and concentrated to dryness. The resulting residue was purified via a Biotage chromatography system (1 Og snap KP-Sil column, hexane / 0 – 100% ethyl acetate, then ethyl acetate / 0 – 100% methanol) to obtain 190 mg (84 % purity, 103 % yield) of the desired title compound. -NMR (400 MHz, DMSO-d6) delta [ppm]: -0.1 1 – -0.06 (m, 9H), 0.79 – 0.86 (m, 2H), 3.54 – 3.61 (m, 2H), 4.62 (d, 2H), 5.68 (s, 2H), 6.58 (d, 1 H), 7.23 (t, 1 H), 7.37 – 7.45 (m, 2H), 7.64 (dd, 1 H), 7.70 (dd, 1 H), 8.28 (d, 1 H), 8.36 (s, 1 H), 9.15 (dd, 1 H), 9.43 (s, 1 H).
93319-65-4 Pyridazin-3-ylmethanamine 22639518, apyridazine compound, is more and more widely used in various fields.
Reference£º
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG; BAYER AKTIENGESELLSCHAFT; BUCHMANN, Bernd; SCHMEES, Norbert; MOWAT, Jeffrey Stuart; LEDER, Gabriele; PANKNIN, Olaf; CARRETERO, Rafael; AIGUABELLA FONT, Nuria; BRIEM, Hans; FRIBERG, Anders Roland; HUSEMANN, Manfred; BOeMER, Ulf; STOeCKIGT, Detlef; NEUHAUS, Roland; BERNDT, Sandra; PETERSEN, Kirstin; OFFRINGA, Rienk; (494 pag.)WO2018/228920; (2018); A1;,
Pyridazine – Wikipedia
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