One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, name: 3-Phenyl-6-chloropyridazine, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 20375-65-9, Name is 3-Phenyl-6-chloropyridazine, molecular formula is C10H7ClN2
A series of novel P1/P1′-substituted cyclic urea-based HIV-1 protease inhibitors was prepared. Three different synthetic schemes were used to assemble these compounds. The first approach uses amino acid-based starting materials and was originally used to prepare DMP 323. The other two approaches use L-tartaric acid or L-mannitol as the starting material. The required four contiguous R,S,S,R centers of the cyclic urea scaffold are introduced using substrate control methodology. Each approach has specific advantages based on the desired P1/P1′ substituent. Designing analogs based on the enzyme’s natural substrates provided compounds with reduced activity. Attempts at exploiting hydrogen bond sites in the S1/S1′ pocket, suggested by molecular modeling studies, were not fruitful. Several analogs had better binding affinity compared to our initial leads. Modulating the compound’s physical properties led to a 10-fold improvement in translation resulting in better overall antiviral activity.
One of the oldest and most widely used commercial enzyme inhibitors is aspirin, name: 3-Phenyl-6-chloropyridazine, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 20375-65-9
Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N2715 – PubChem