One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, Recommanded Product: 3,6-Dichloro-4,5-dimethylpyridazine, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 34584-69-5, Name is 3,6-Dichloro-4,5-dimethylpyridazine, molecular formula is C6H6Cl2N2
C-terminal Src kinase (CSK) functions as a negative regulator of T cell activation through inhibitory phosphorylation of LCK, so inhibitors of CSK are of interest as potential immuno-oncology agents. Screening of an internal kinase inhibitor collection identified pyridazinone lead 1, and a series of modifications led to optimized compound 13. Compound 13 showed potent activity in biochemical and cellular assays in vitro and demonstrated the ability to increase T cell proliferation induced by T cell receptor signaling. Compound 13 gave extended exposure in mice upon oral dosing and produced a functional response (decrease in LCK phosphorylation) in mouse spleens at 6 h post dose.
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Recommanded Product: 3,6-Dichloro-4,5-dimethylpyridazine, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 34584-69-5, in my other articles.
Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N2473 – PubChem