With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1837-55-4,3,5-Dichloropyridazine,as a common compound, the synthetic route is as follows.
A mixture of 3,5-dichloropyridazine(l .00 g, 6.71 mmol) and liquid Nfb was stirred in a sealed tube for 12 h. A black residue was formed. The residue was purified by Combi Flash (50% to 100% EtOAc in pentane) to give 5-chloropyridazin-3-amine (400 mg, yield: 44%) as a yellow solid. (1582) NMR (400 MHz DMSO-rie) d 6.66 (1H, d, J= 2.3 Hz), 6.84 (2H, brs), 8.50 (1H, d, J= 2.3 Hz).
The synthetic route of 1837-55-4 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; PETRA PHARMA CORPORATION; KESICKI, Edward A.; LINDSTROeM, Johan; PERSSON, Lars Boukharta; VIKLUND, Jenny; FORSBLOM, Rickard; GINMAN, Tobias; HICKEY, Eugene R.; DAHLGREN, Markus K.; GERASYUTO, Aleksey I.; (391 pag.)WO2019/126730; (2019); A1;,
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