With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.289-80-5,Pyridazine,as a common compound, the synthetic route is as follows.
General procedure: To a mixture of spirocyclopropenes 1a-c (25 mmol) in 100 mL freshly dried ether at room temperature was added under dry N2 and in absence of light, substituted pyridazines 2a-d (26 mmol). The mixture was stirred at room temperature for 24 h (TLC-monitored). The ether was removed under reduced pressure and the pure products were obtained after being subjected at least twice to column chromatography on silica gel using dichloromethane as eluent to afford the photochromic products 3a-f in low to moderate yields. Experimental details and full characterizations of the new synthesized DHIs 3a-f are described below:, 289-80-5
As the paragraph descriping shows that 289-80-5 is playing an increasingly important role.
Reference£º
Article; Ahmed, Saleh A.; Hozien, Zeinab A.; Abdel-Wahab, Aboel-Magd A.; Al-Raqa, Shaya Y.; Al-Simaree, Abdulrahman A.; Moussa, Ziad; Al-Amri, Saleh N.; Messali, Mouslim; Soliman, Ahmed S.; Duerr, Heinz; Tetrahedron; vol. 67; 37; (2011); p. 7173 – 7184;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem