With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.867130-58-3,6-Oxo-1,6-dihydropyridazine-4-carboxylic acid,as a common compound, the synthetic route is as follows.
867130-58-3, Example 16-oxo-5,6-dihydro-pyridazine-4-carboxylic acid-(1-{[5-(4-fluoro-2-trifluoromethyl-phenylamino)-pyridin-2-ylmethyl]-carbamoyl}-cyclopropyl)-amide Prepared from intermediate C2 and 6-oxo-1,6-dihydro-pyridazine-4-carboxylic acid according to AAV1. AAV 1: Amide CouplingA solution of the carboxylic acid component (1 mol-equivalent), triethylamine (2.5 mol-equivalents) and TBTU (1.1 mol-equivalents) in THF was stirred for 30 minutes at ambient temperature. Then the amine component (1.1 mol-equivalent as hydrochloride) was added and stirring was continued overnight. Then the mixture was evaporated down, mixed with water, made alkaline with dilute potassium carbonate solution and extracted with ethyl acetate. The product was isolated and purified by column chromatography (either silica gel or reversed phase chromatography).
867130-58-3 6-Oxo-1,6-dihydropyridazine-4-carboxylic acid 12376265, apyridazine compound, is more and more widely used in various fields.
Reference£º
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; US2012/142695; (2012); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem