With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.19064-64-3,3,6-Dichloro-4-methylpyridazine,as a common compound, the synthetic route is as follows.
Example 136 Alternative Method 16 2-Chloro-N-{5-methyl-6-[4-(piperidine-1-sulfonyl)-phenylsulfanyl]-pyridazin-3-yl}-4-trifluoromethyl-benzenesulfonamide (136) Step 1: 6-Chloro-5-methyl-pyridazin-3-ylamine and 6-chloro-4-methyl-pyridazin-3-ylamine; 3,6-Dichloro-4-methylpyridazine (10 g) was mixed with ammonium hydroxide (62 mls) and heated at 135 C. in a sealed vessel at 12 Bar for 20 hours. The mixture was allowed to cool and all volatiles removed in vacuo. The crude material was pre-absorbed onto silica using methanol and purified by flash chromatography using methanol 0-5% in dichloromethane. Two fractions were isolated, Fraction 1 3.86g of a 1:0.66 Isomer A to Isomer B and Fraction 2-3.40g of a 1:2.5 mixture Isomer A to Isomer B. Fraction 1 1H NMR (CDCl3) 7.0 (1H, s) 6.6 (0.66H, s) 4.9 (broad) 2.25 (3H, s) 2.15 (2H, s). Fraction 2 1H NMR (CDCl3) 7.0 (1H, s) 6.6 (2.5H, s) 4.7(broad) 2.25 (8H, s) 2.1(3H,s), 19064-64-3
As the paragraph descriping shows that 19064-64-3 is playing an increasingly important role.
Reference£º
Patent; Bergeron, Philippe; Farthing, Christopher N.; Jones, Stuart D.; Liebeschuetz, John W.; Lively, Sarah E.; McGee, Lawrence R.; McKendry, Sharon; Sheppard, David; Young, Stephen C.; US2006/84802; (2006); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem