With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5469-69-2,3-Amino-6-chloropyridazine,as a common compound, the synthetic route is as follows.
5469-69-2, Synthesis of pyridazin-3 -amine:To a stirred solution of 6-chloropyridazin-3 -amine (10 g, 77.19 mmol) in MeOH (100 mL) was added 10% Pd-C (2.5 g), diethyl amine (16.0 mL, 154.38 mmol) and stirred at RT for 16 h under ? atmosphere (balloon pressure). The reaction mixture was passed through a pad of celite and washed with MeOH (10 mL). Volatiles were dried in vacuo to afford pyridazin-3 -amine (7.3 g) as a crude. This was used for next step without further purification. 1H-NMR (DMSO d6, 500 MHz): delta 8.84 (br s, 2H), 8.41-8.38 (m, 1H), 7.22- 7.18 (m, 1H), 6.74 (d, 1H); LC-MS: 78.43%; 95.9 (M++l); (column; X-bridge C-18, (50×3.0 mm, 3.5mu); RT 0.68 min. 5mM AA in water: ACN; 0.5 ml/min); TLC: 100% EtOAc (Rf: 0.2).
5469-69-2 3-Amino-6-chloropyridazine 21643, apyridazine compound, is more and more widely used in various fields.
Reference£º
Patent; ENVIVO PHARMACEUTICALS, INC.; RIPKA, Amy; SHAPIRO, Gideon; MCRINER, Andrew; WO2012/40230; (2012); A1;,
Pyridazine – Wikipedia
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