With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.88497-27-2,3-Amino-6-bromopyridazine,as a common compound, the synthetic route is as follows.
1-(6-Amino-3-pyridazinyl)-2(1H)-pyridinone A microwave vial was charged with copper(I) iodide (10.01 mg, 0.053 mmol) and potassium carbonate (291 mg, 2.103 mmol), evacuated and backfilled with nitrogen. 2(1H)-pyridinone (100 mg, 1.052 mmol), 6-bromo-3-pyridazinamine (183 mg, 1.052 mmol) and N,N-Dimethylformamide (4 ml) was added under nitrogen. The vial was sealed and the reaction mixture was stirred at 130 C. for 3 hours. The solvent was evaporated. Dichloromethane (5 ml) was added to the residue and it was filtered washing with more dichloromethane (2*1 ml). The residue was purified by silica gel chromatography via Biotage (10%-50% DCMMeOH) to give 1-(6-amino-3-pyridazinyl)-2(1H)-pyridinone (51 mg, 0.271 mmol, 26%). 1H NMR (400 MHz, CDCl3): delta 4.93 (br s, 1H), 5.05 (br s, 1H), 5.46 (br s, 1H), 6.04 (br s, 2H), 6.22 (brs, 1H); UPLC-MS: 0.36 min, 189 [M+H]+., 88497-27-2
The synthetic route of 88497-27-2 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Biagetti, Matteo; Contini, Stefania Anna; Genski, Thorsten; Guery, Sebastien; Leslie, Colin Philip; Mazzali, Angelica; Pizzi, Domenica Antonia; Sabbatini, Fabio Maria; Seri, Catia; US2009/203705; (2009); A1;,
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