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A series of dual-target AChE/PDE9A inhibitor compounds were designed, synthesized, and evaluated as anti-Alzheimer’s Disease (AD) agents. Among these target compounds, 11a (AChE: IC50 = 0.048 muM; PDE9A: IC50 = 0.530 muM) and 11b (AChE: IC50 = 0.223 muM; PDE9A: IC50 = 0.285 muM) exhibited excellent and balanced dual-target AChE/PDE9A inhibitory activities. Meanwhile, those two compounds possess good blood-brain barrier (BBB) penetrability and low neurotoxicity. Especially, 11a and 11b could ameliorate learning deficits induced by scopolamine (Scop). Moreover, 11a could also improve cognitive and spatial memory in Abeta25-35-induced cognitive deficit mice in the Morris water-maze test. In summary, our research developed a series of potential dual-target AChE/PDE9A inhibitors, and the data indicated that 11a was a promising candidate drug for the treatment of AD.
Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.Recommanded Product: 3-Phenyl-6-chloropyridazine, you can also check out more blogs about20375-65-9
Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N2650 – PubChem