With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.135034-10-5,3-Chloro-6-iodopyridazine,as a common compound, the synthetic route is as follows.
b) Ethyl (?)-3-(3-Chloro-6-pyridazinyl)-2-propenoate.; A suspension of 3- chloro-6-iodopyridazine (2.4 g, 10 mmol), ethyl acrylate (4.4 mL, 40 mmol), palladium(II) acetate (90 mg, 0.40 mmol) and tri(o-tolyl)phosphine (366 mg, 1.20 mmol) in DMF (10 mL) and diisopropylethyl amine (5 mL) was stirred with heating (1 1 1 C oil-bath) for 3.5 h, cooled to room temperature, diluted with H20 (50 mL) and extracted with EtOAc (300 mL). The extract was washed (brine) and dried. After solvent removal at reduced pressure, the residue was chromatographed (14% to 20% EtOAc/hexane) to give 174 mg (8%) of ethyl (E)-3- (3-chloro-6-pyridazinyl)-2-propenoate as a brown solid, mp 106-1 10 C. IR 2928, 1715, 1 186 cm”1; 1H NMR (CDC13) delta 1.38 (t, J= 7.5 Hz, 3H, CH2G?), 4.33 (q, J= 7.5 Hz, 2H, CH2CH3), 7.98 (d, J = 16.2 Hz, 1H, CH=CHCO), 7.57 (d, J= 8.4 Hz, 1H, 4-ArH), 7.63 (d, J = 8.4 Hz, 1H, 5-ArH), 7.86 ppm (d, J= 16.2 Hz, 1H, CH=CHCO). HRMS calcdC9H9C1N202 [M + H]+ 213.0425, found 213.0431., 135034-10-5
As the paragraph descriping shows that 135034-10-5 is playing an increasingly important role.
Reference£º
Patent; WAYNE STATE UNIVERSITY; SANDFORD-BURNHAM MEDICAL RESEARCH INSTITUTE; FONTANA, Joseph, A.; DAWSON, Marcia; XIA, Zebin; WO2011/79305; (2011); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem