372118-01-9, Methyl 4,6-dichloropyridazine-3-carboxylate is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Compound 4-((tetrahydro-2H-thian-4-yl) oxy) aniline 45c (200 mg, 0.955 mmol)And 4,6-dichloropyridazine-3-carboxylic acid methyl ester 1a (200 mg, 0.97 mmol) in ethanol (10 mL),Heat to 90 C in a sealed tube and stir for 12 hours.After cooling to room temperature, the solvent was removed under reduced pressure, and the residue was purified by silica gel column chromatography (petroleum ether / ethyl acetate = 1/1 to 1/2),The target product 6-chloro-4-((4-((tetrahydro-2H-thian-4-yl) oxy) phenyl) amino) pyridazine-3-carboxylic acid methyl ester 45d (240 mg, yellow solid ),Yield: 66%.
372118-01-9, The synthetic route of 372118-01-9 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Beijing Nuochengjianhua Pharmaceutical Technology Co., Ltd.; Chen Xiangyang; Pang Yucheng; (142 pag.)CN110818641; (2020); A;,
Pyridazine – Wikipedia
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