141-30-0, Name is 3,6-Dichloropyridazine, belongs to pyridazine compound, is a common compound. SDS of cas: 141-30-0In an article, once mentioned the new application about 141-30-0.
3-[(6-Arylamino)pyridazinylamino]benzoic acids: Design, synthesis and in vitro evaluation of anticancer activity
A series of novel substituted 3,6-disubstituted pyridazines based on the structure of vatalanib (PTK787) were designed and synthesized. The cytotoxicity of the final compounds was tested in vitro on HT-29 colon cancer cell line. Compounds 2a and 2b with 4-chlorophenylamino moiety, exerted the highest cytotoxic activity with IC50 values equal to 15.3 and 3.9 muM respectively. The most promising compound, 2b, was found to be about fivefold more active than vatalanib against HT-29 colon cancer cell line.
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Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N1585 – PubChem