One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, Formula: C5H5ClN2, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 1121-79-5, Name is 3-Chloro-6-methylpyridazine, molecular formula is C5H5ClN2
Identification, synthesis, and biological evaluation of 6-[(6 R)-2-(4-fluorophenyl)-6-(hydroxymethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a ]pyrimidin-3-yl]-2-(2-methylphenyl)pyridazin-3(2 H)-one (AS1940477), a potent p38 MAP kinase inhibitor
Several p38 MAPK inhibitors have been shown to effectively block the production of cytokines such as IL-1beta, TNFalpha, and IL-6. Inhibitors of p38 MAP kinase therefore have significant therapeutic potential for the treatment of autoimmune disease. Compound 2a was identified as a potent TNFalpha production inhibitor in vitro but suffered from poor oral bioavailability. Structural modification of 2a led to the discovery of tetrahydropyrazolopyrimidine derivatives, exemplified by compound 3, with an improved pharmacokinetic profile. We found that blocking metabolism at the methyl group of the amine and constructing the tetrahydropyrimidine core were important to obtaining compounds with good biological profiles and oral bioavailability. Pursuing the structure-activity relationships of this series led to the discovery of AS1940477 (3f), with excellent cellular activity and a favorable pharmacokinetic profile. This compound represents a highly potent inhibitor of p38 MAP kinase with regard to in vivo activity in an adjuvant-induced arthritis model.
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Formula: C5H5ClN2, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 1121-79-5, in my other articles.
Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N646 – PubChem