90008-50-7, Name is 6-Propoxypyridazin-3-amine, belongs to pyridazine compound, is a common compound. Formula: C7H11N3OIn an article, once mentioned the new application about 90008-50-7.
Syntheses, pharmacological evaluation and molecular modelling of substituted 6-alkoxyimidazo<1,2-b>pyridazines as new ligands for the benzodiazepine receptor
A series of 2,3-disubstituted-6-alkoxyimidazo<1,2-b>pyridazines has been synthesized and evaluated for in vitro affinity for the benzodiazepine receptor (BZR). 3-(Benzamidomethyl or substituted benzamidomethyl)-6-methoxy-2-(3,4-methylenedioxyphenyl)imidazo<1,2-b>pyridazines were found to be the most potent BZR ligands (eg, 4a, IC50 7 nM; 4e, IC50 14 nM; 4v, IC50 8 nM).Imidazo<1,2-b>pyridazines unsubstituted in the 3-position, or containing bulkier alkoxy groups in the 6-position, were found to bind less strongly to the BZR.Selected compounds from the series wereidentified from in vitro GABA-shift experiments as BZR agonists.Molecular modelling has been employed to identify the common pharmacophoric points of lipophilic and hydrogen bonding, ligand-receptor interaction and areas of steric hindrance for these substituted imidazo<1,2-b>pyridazines at the BZR. – Keywords: imidazo<1,2-b>pyridazine; benzodiazepine receptor; structure-activity relationship; molecullar modelling
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Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N1987 – PubChem