With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.932-22-9,4,5-Dichloro-3(2H)-pyridazinone,as a common compound, the synthetic route is as follows.
Synthesis of 4.5-dichloro-2-((3-chloropyridin-4-yl”)methyl”)pyridazin-3(2HVone (G3-1″) 30 G3-1 To a solution of compound 4 (200 mg, 1.21 mmol), compound 30 (235 mg, 1.45 mmol) and K2C03 (335 mg, 2.42 mmol) in DMF (3 mL) was added KI (20 mg, 0.12 mmol). The solution was stirred at 90 C for 2h. The mixture was cooled to room temperature and quenched with water, extracted with EtOAc for 3 times, combined the organic layer, washed with brine, dried over Na2S04, filtered, concentrated under reduced pressure, purified by HPLC to give G3-1 (135 mg, 47%) as a brown solid. NMR (DMSO-(3?6, 300 MHz): delta 5.40 (s, 2H), 7.23 (d, J= 5.1 Hz, 1H), 8.31 (s, 1H), 8.47 (d, J = 4.8 Hz, 1H), 8.67 (s, 1H); LCMS [mobile phase: 20-95% Acetonitrile +0.02% NH40Ac] purity is >95%, Rt = 3.163 min; MS 291; MS Found: 292 (M+l)+.
932-22-9 4,5-Dichloro-3(2H)-pyridazinone 73247, apyridazine compound, is more and more widely used in various.
Reference£º
Patent; PRESIDENT AND FELLOWS OF HARVARD COLLEGE; BECKWITH, Jonathan Roger; DUTTON, Rachel; ESER, Markus; LANDETA, Cristina; BLAZYK, Jessica L.; MEEHAN, Brian M.; HATAHET, Feras; BOYD, Dana; WO2015/143164; (2015); A1;,
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