20698-04-8, 3,6-Diiodopyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
I II.5. a 3-lodo-6-phenethyl-pyridazine To 200 ml (100 mmol) 0,5 M phenylethylzincbromid solution in THF are added dropwise a mixture of 26,55 g (80 mmol) 3,6 Diiodopyridazine and 4,622 g (4 mmol) Tetrakis(triphenylphosphine) palladium(O) in 100 ml abs. THF. The reaction mixture is stirred for 3 hours at room temperature. Then the mixture is poured in saturated sodium hydrogencarbonate solution and ethyl acetate is added. The mixture is filtered over Celite and the phases are separated. The organic phase is dried over sodium sulphate. Purification is achieved by chromatography (silica gel, methylene chloride/ ethyl acetate= 19:1 ). Yield: 13,97 g (56 % of theory),Rf value: 0.47 (silica gel, methylene chloride/ethyl acetate= 19:1 )EII mass spectrum: m/z = 31 1 [M+H]+
20698-04-8, The synthetic route of 20698-04-8 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GmbH; BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG; WO2008/71646; (2008); A1;,
Pyridazine – Wikipedia
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