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7252-84-8 3-Amino-6-methoxypyridazine 81673, apyridazine compound, is more and more widely used in various fields.

7252-84-8,7252-84-8, 3-Amino-6-methoxypyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Method 2: (0084) Dissolve 2-chloro-4-(1-cyclopropyl-3-tetrahydropyran-4-yl-pyrazol-4-yl)oxy-pyridine (400 mg, 1.2 mmol) in 1,4-dioxane (15 mL) in a vial. Add 2-(4-amino-2-pyridyl)propan-2-ol (266.5 mg, 1.6 mmol), cesium carbonate (568.5 mg, 1.7 mmol), 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene (134.6 mg, 0.23 mmol) and purge with nitrogen for 5 minutes. Add palladium(II)acetate (26.1 mg, 0.12 mmol) and purge with nitrogen for 5 minutes. Seal the vial and stir at 100 C. overnight. Cool the reaction to room temperature, filter through a CELITE plug and wash with 5% MeOH in DCM. Concentrate and purify by reverse phase chromatography (Redisep Rf Gold High Performance C18 Reverse Phase Column, 0-100% formic acid/acetonitrile (ACN) in formic acid/water). Concentrate appropriate fractions and dry under vacuum to give the title compound (341 mg; 67.3% yield). MS (m/z): 436 (M+1).

7252-84-8 3-Amino-6-methoxypyridazine 81673, apyridazine compound, is more and more widely used in various fields.

Reference£º
Patent; ELi Lilly and Company; MCMILLEN, William T.; JOSEPH, Sajan; PARTHASARATHY, Saravanan; PEI, Huaxing; SAWYER, Jason Scott; BEIGHT, Douglas W.; ZHAO, Gaiying; COATES, David A.; WOLFANGEL, Craig D.; (43 pag.)US2016/96823; (2016); A1;,
Pyridazine – Wikipedia
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