With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.21141-03-7,3-Amino-4-pyridazinecarboxylic acid,as a common compound, the synthetic route is as follows.
3-Aminopyridazine-4-carboxylic acid (200 mg, 1.43 mmol) and benzaldehyde(0.18 mL, 1.73 mmol) were stirred in DMF (3 mL) at 90 C for four days. The reaction mixture was allowed to cool tort and sodium triacetoborohydride (605 mg, 2.86 mmol) was added. The reaction was stirred for 16 h. The reaction was quenched with water and extracted with EtOAc. The extracts were dried (Na2S04) and concentrated. The residuewas purified by column chromatography (0-20% MeOH/DCM). The relevant fractionswere concentrated to give 6.3 mg (4%) of the title compound. 1H NMR (500 MHz, DMSO-d6): 8 8.51 (d, 1H, 5Hz), 7.63 (d, 1H, J = 5.0 Hz), 7.30-7.39 (m, 4H), 7.22-7.25 (m, 1H), 4.72 (br s, 2H). [M+H] calc’d for C1zHuN302, 230; found 230.
21141-03-7, The synthetic route of 21141-03-7 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; QUANTICEL PHARMACEUTICALS, INC.; CHEN, Young, K.; KANOUNI, Toufike; NIE, Zhe; STAFFORD, Jeffrey, Alan; VEAL, James, Marvin; WALLACE, Michael, Brennan; WO2014/100818; (2014); A1;,
Pyridazine – Wikipedia
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