Electric Literature of 16082-13-6, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 16082-13-6, Name is Diethyl pyridazine-3,4-dicarboxylate, molecular formula is C10H12N2O4. In a Article£¬once mentioned of 16082-13-6
Design and optimization of tricyclic phtalimide analogues as novel inhibitors of HIV-1 integrase
Human immunodeficiency virus type-1 integrase is an essential enzyme for effective viral replication and hence a valid target for the design of inhibitors. We report here on the design and synthesis of a novel series of phthalimide analogues as integrase inhibitors. The short synthetic pathway enabled us to synthesize a series of analogues with a defined structure diversity. The presence of a single carbonyl-hydroxy-aromatic nitrogen motif was shown to be essential for the enzymatic activity and this was confirmed by molecular docking studies. The enzymatically most active compound from this series is 7-(3,4-dichlorobenzyl)-5,9-dihydroxypyrrolo[3,4-g]quinoxaline-6,8- dione (15l) with an IC50 value of 112 nM on the HIV-1 integrase enzyme, while ((7-(4-chlorobenzyl)-5,9-dihydroxy-pyirolo[3,4-g]quinoxaline-6,8- dione (15k)) showed an EC50 of 270 nM against HIV-1 in a cell-based assay.
Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Electric Literature of 16082-13-6. In my other articles, you can also check out more blogs about 16082-13-6
Reference£º
Pyridazine – Wikipedia,
Pyridazine | C4H4N3006 – PubChem