With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.19064-67-6,6-Chloro-3-hydroxypyridazine,as a common compound, the synthetic route is as follows.
To a solution of 6-chloropyridazin-3(2H)-one (0.35 g, 2.68 mmol) in DMF (10 mL) was added K2CO3 (0.93 g, 6.70 mmol) and methyl iodide (0.20 mL, 3.22 mmol). The resulting mixture was stirred at 25 C for 1 h. To the reaction mixture was added ice cold water (30 mL) and the mixture was extracted with ethyl acetate (2 x 50 ml). The combined organic layers were washed with brine (30 mL), dried over sodium sulfate and distilled under reduced pressure to obtain Intermediate 107 (0.25 g, 56.10%) as an off white solid.1H NMR (400 MHz, CDCl3) delta ppm 3.75 (s, 3 H), 6.92 (d, J = 9.76 Hz, 1 H), 7.19 (d, J = 9.76 Hz, 1 H). LCMS (Method-D): retention time 0.66 min, [M+1] 145.2.
19064-67-6, As the paragraph descriping shows that 19064-67-6 is playing an increasingly important role.
Reference£º
Patent; BRISTOL-MYERS SQUIBB COMPANY; GUNAGA, Prashantha; BHIDE, Rajeev S.; BORA, Rajesh Onkardas; PANDA, Manoranjan; YADAV, Navnath Dnyanoba; PRIESTLEY, Eldon Scott; RICHTER, Jeremy; (321 pag.)WO2018/93569; (2018); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem