In an article, author is Aggarwal, Ranjana, once mentioned the application of 1538-08-5, Name is 2,2,2-Trifluoroacetohydrazide, molecular formula is C2H3F3N2O, molecular weight is 128.05, MDL number is MFCD00221440, category is pyridazines. Now introduce a scientific discovery about this category, Application In Synthesis of 2,2,2-Trifluoroacetohydrazide.
Synthesis and structural studies of 3,6-disubstituted-bis-1,2,4-triazolo-[4,3-b][3 ‘,4 ‘-f]pyridazines
Synthesis of a series of 3,6-disubstituted-bis-1,2,4-triazolo-[4,3-b][3′,4′-f]pyridazines (4) was accomplished by the oxidative intramolecular cyclization of 6-arylidenehydrazino-3-aryl-1,2,4-triazolo[4,3-b]pyridazine (3) using iodobenzene diacetate (IBD), as a green oxidant, in dichloromethane at room temperature. The compounds 3 and 4 were characterized by IR, NMR (H-1 and C-13), mass spectral data and elemental analyses. X-ray crystal analysis of sterically strained 3,6-di-(2′-fluorophenyl)-bis-1,2,4-triazolo-[4,3-b][3′,4′-f]pyridazine 4f and 3,6-di-(4′-fluorophenyl)-bis-1,2,4-triazolo-[4,3-b][3′,4’-f]pyridazine 4g indicated that pyridazine ring has twisted conformation leading to nonplanar tricyclic core. Both compounds crystallized in orthorhombic P2(1)2(1)2(1) space group, containing one single molecule per asymmetric unit. The studies reveal that the compound 4f is associated with weak, centrosymmetric F center dot center dot center dot F interactions (distance of 2.882(3) angstrom), with cis geometry, between adjacent molecules which are responsible for the formation of chains along a axis. Additionally, compounds 4 were screened for their cytotoxic activity against the human cervical carcinoma (HeLa) cell line using MTT assay, however, with not much significant activity. (C) 2019 Elsevier B.V. All rights reserved.
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Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem