Electric Literature of 1538-08-5, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 1538-08-5, Name is 2,2,2-Trifluoroacetohydrazide, SMILES is NNC(=O)C(F)(F)F, belongs to pyridazines compound. In a article, author is Moir, M., introduce new discover of the category.
Ring-opened aminothienopyridazines as novel tau aggregation inhibitors
Aminothienopyridazines (ATPZs) have demonstrated efficacy, in vitro, as tau protein aggregation inhibitors. Modifications were made to the ATPZ scaffold to determine the importance of certain structural features for activity. More specifically, ring-opened analogues detached at the nitrogen-nitrogen bond of the pyridazine, were synthesized and their inhibitory activity evaluated. Preliminary data suggests that the ring-opened structures retain inhibitory activity, independent of tau oxidation. The structures detailed represent the beginnings of a deconstruction-reconstruction-elaboration study, with the aim of identifying simpler scaffolds, which retain activity and can be optimized in terms of physiochemical properties.
Electric Literature of 1538-08-5, One of the oldest and most widely used commercial enzyme inhibitors is aspirin, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 1538-08-5.
Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem