Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 455-24-3, Name is 4-(Trifluoromethyl)benzoic acid, molecular formula is C8H5F3O2. In an article, author is Hashem, Heba E.,once mentioned of 455-24-3, Safety of 4-(Trifluoromethyl)benzoic acid.
Synthesis of new annulated pyridazine derivatives and studying their antioxidant and antimicrobial activities
Benzil was reacted with cyanoacetohydrazide under microwave irradiation to give 3-oxo-5,6-diphenyl-2,3-dihydropyridazine-4-carbonitrile 1 which used as starting material for the synthesis of new heterocyclic compounds. Chlorination of pyridazinone 1 with POCl3 afforded the chloro-pyridazine derivative 3, which then condensed with 2-aminothiazole or hydrazine hydrate to produce 3,4-diphenyl-5H-thiazolo[3 ‘,2 ‘:1,2]pyrimido[4,5-c]pyridazin-5-one 5 or 3-hydrazinyl-5,6-diphenylpyridazine-4-carbonitrile 6, respectively. New Schiff bases were obtained by condensation reactions of compound 6 with different aldehydes. On the other hand, compound 6 reacted with different carbon electrophiles naming acetyl acetone, diethyl malonate, and phenyl isothiocyanate producing new pyarazolo-pyridazine derivatives 11, 12, and 14, respectively. Chemical structures of all newly synthesized compounds were confirmed on the basis of spectral data and had been screened for antimicrobial and antioxidant activity.
Interested yet? Keep reading other articles of 455-24-3, you can contact me at any time and look forward to more communication. Safety of 4-(Trifluoromethyl)benzoic acid.
Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem