Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, Recommanded Product: 1799-84-4, 1799-84-4, Name is 3,3,4,4,5,5,6,6,6-Nonafluorohexyl methacrylate, SMILES is CC(C(OCCC(F)(F)C(F)(F)C(F)(F)C(F)(F)F)=O)=C, belongs to pyridazines compound. In a document, author is Velaparthi, Upender, introduce the new discover.
Discovery of BMS-986260, a Potent, Selective, and Orally Bioavailable TGF beta R1 Inhibitor as an Immuno-oncology Agent
Novel imidazole-based TGF beta R1 inhibitors were identified and optimized for potency, selectivity, and pharmacokinetic and physicochemical characteristics. Herein, we report the discovery, optimization, and evaluation of a potent, selective, and orally bioavailable TGF beta R1 inhibitor, 10 (BMS-986260). This compound demonstrated functional activity in multiple TGF beta-dependent cellular assays, excellent kinome selectivity, favorable pharmacokinetic properties, and curative in vivo efficacy in combination with anti-PD-1 antibody in murine colorectal cancer (CRC) models. Since daily dosing of TGF beta R1 inhibitors is known to cause class-based cardiovascular (CV) toxicities in preclinical species, a dosing holiday schedule in the anti-PD-1 combination efficacy studies was explored. An intermittent dosing regimen of 3 days on and 4 days off allowed mitigation of CV toxicities in one month dog and rat toxicology studies and also provided similar efficacy as once daily dosing.
A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 1799-84-4. Recommanded Product: 1799-84-4.
Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem