Related Products of 1538-08-5, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 1538-08-5, Name is 2,2,2-Trifluoroacetohydrazide, SMILES is NNC(=O)C(F)(F)F, belongs to pyridazines compound. In a article, author is Duke, Angela N., introduce new discover of the category.
Evidence That Sedative Effects of Benzodiazepines Involve Unexpected GABA(A) Receptor Subtypes: Quantitative Observation Studies in Rhesus Monkeys
In nonhuman primates we tested a new set of behavioral categories for observable sedative effects using pediatric anesthesiology classifications as a basis. Using quantitative behavioral observation techniques in rhesus monkeys, we examined the effects of alprazolam and diazepam (nonselective benzodiazepines), zolpidem (preferential binding to alpha 1 subunit-containing GABA(A) receptors), HZ-166 (8-ethynyl-6-(2′-pyridine)-4H-2,5,10b-triaza-benzo[e]azulene-3-carboxylic acid ethyl ester; functionally selective with relatively high intrinsic efficacy for alpha 2 and alpha 3 subunit-containing GABA(A) receptors), MRK-696 [7-cyclobutyl-6-(2-methyl-2H-1,2,4-triazol-2-ylmethoxy)-3-(2-flurophenyl)-1,2,4-triazolo(4,3-b) pyridazine; no selectivity but partial intrinsic activity], and TPA023B 6,2′-diflouro-5′-[3-(1-hydroxy-1-methylethyl)imidazo[1,2-b][1,2,4]triazin-7-yl]biphenyl-2-carbonitrile; partial intrinsic efficacy and selectivity for alpha 2, alpha 3, alpha 5 subunit-containing GABA(A) receptors]. We further examined the role of alpha 1 subunit-containing GABA(A) receptors in benzodiazepine-induced sedative effects by pretreating animals with the alpha 1 subunit-preferring antagonist beta-carboline-3-carboxylate-t-butyl ester (beta CCT). Increasing doses of alprazolam and diazepam resulted in the emergence of observable ataxia, rest/sleep posture, and moderate and deep sedation. In contrast, zolpidem engendered dose-dependent observable ataxia and deep sedation but not rest/sleep posture or moderate sedation, and HZ-166 and TPA023 induced primarily rest/sleep posture. MRK-696 induced rest/sleep posture and observable ataxia. Zolpidem, but no other compounds, significantly increased tactile/oral exploration. The sedative effects engendered by alprazolam, diazepam, and zolpidem generally were attenuated by beta CCT pretreatments, whereas rest/sleep posture and suppression of tactile/oral exploration were insensitive to beta CCT administration. These data suggest that alpha 2/3-containing GABA(A) receptor subtypes unexpectedly may mediate a mild form of sedation (rest/sleep posture), whereas alpha 1-containing GABA(A) receptors may play a role in moderate/deep sedation.
Related Products of 1538-08-5, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 1538-08-5.
Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem