Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, Name: 3-Amino-6-chloropyridazine, 5469-69-2, Name is 3-Amino-6-chloropyridazine, SMILES is C1=C(N=NC(=C1)Cl)N, belongs to pyridazines compound. In a document, author is El-Sayed, Hassan A., introduce the new discover.
Cyanoacetic acid hydrazide: An efficient access for the synthesis of multi-functional azine and azole derivatives
Herein, the synthesis of nitrogen-containing heterocyclic scaffolds from heterocyclization of cyanoacetic acid hydrazide derivatives is described. Thiosemicarbazide derivative 1a undergoes base-mediated cyclization producing pyrazole derivative of type 2. The triazolopyridine 5 was obtained by double cyclization of 1a and benzylidene malononitrile. Compound 1b condensed with ethyl chloroformate to furnish pyrazolooxazine 8. Compound 1b was added to benzoyl isothiocyanate under thermal condition to form oxadiazine derivative 10 while, keeping the above reactant under room temperature to form acyclic derivative 11. Using CS2 as a cyclizing agent for compound 1b yielded pyrazole derivative 13. Treatment of 1b with I-2 resulted in oxidative cyclization producing pyridazine derivative 14. Compound 1c cyclized with benzoyl isothiocyanate forming triazolothiazine derivative 18. While using cinnamoyl isothiocyanate, the acyclic product 22 was obtained. Compound 1c was condensed with formaldehyde leading to oxadiazole derivative 25.
A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 5469-69-2. Name: 3-Amino-6-chloropyridazine.
Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem